Inhaled tuberculosis vaccine – a gateway to affordable and non-invasive drug delivery
Posted by evolvingwheel on March 13, 2008
Several months back I mentioned about saliva as a source of biomarkers for different diseases. The theme of my post was to delineate the non-invasive and easy-to-administer features of a method that could be used in developing areas of the world where harsh environmental conditions, lack of trained resources, and ignorance pose potent threats to proper diagnosis. This posting comes under the same theme of affordable diagnosis and drug administration where the sturdy nature of the delivery methodology makes it easier to transport, store, distribute, and apply medication among masses of population who often survive on less than $1 a day.
Researchers from Harvard University and an Int’l nonprofit Medicine in Need (MEND) have come up with an aerosol version of a common TB vaccine that can be applied as an aerosol mist. The differentiator is the aerosol delivery using nanoparticle technology that may change the current immunization delivery platform altogether. In the hot countries of Africa and Asia, some of the most difficult challenges are storage and sterility of injection needles. This method, which is currently being tested on animals with highly positive outcomes, if successfully implemented among the human population, can add a whole new horizon of social innovation in immunization for the most needy. A more detailed information about the method and their pioneering inventors can be found [here].
Even in the western hemisphere, this new method, if proven successful, can put the industry of drug delivery upside down. Such a scientific innovation could instantiate a process overhaul among several other collateral supporting industries that provide us with needles, storage, delivery medium, etc. Several years back my friend was using the Asthma inhaler called AdvAir. I was really impressed by the easy-to-use style of the delivery medium – air! If a similar technology could be brought over for the Flu vaccine, I wonder what will be the impact on the society where immunization will be a matter of few seconds and the candidate doesn’t even need to be in a clinic or a healthcare facility. Another major dimensional change will be if the immunization becomes a OTC activity.